Treatment Resistant Depression - Synapse Behavioral

Care for Treatment-resistant Depression in South Jersey

Treatment-resistant depression affects millions of people, but it doesn't mean you're out of options. Our psychiatrists in Marlton, New Jersey, specialize in advanced treatments for depression that hasn't responded to traditional approaches, including TMS therapy, Spravato, and comprehensive medication strategies.

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What is Treatment-resistant Depression (TRD)?

Treatment-resistant depression is diagnosed when depression symptoms haven't adequately improved after trying at least two different antidepressants at adequate doses for an adequate duration (typically 6-8 weeks each).

You’re Not Alone

TRD affects up to one-third of people with major depression. Medical advances have given us powerful new tools to help people who haven't responded to traditional treatments.

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Standard Treatment Approaches for Depression

Before exploring advanced options for treatment-resistant depression, we may first recommend these standard medication strategies.

Medication switching:

Trying antidepressants from different classes that work through different mechanisms

Combination therapy:

Using two antidepressants together that work through different pathways

Augmentation:

Adding a second medication to boost the effectiveness of your current antidepressant (such as atypical antipsychotics, lithium, or thyroid hormone)

Pharmacogenetic testing:

Genetic testing to identify which medications your body metabolizes best and which to avoid

Advanced Treatment Options When Traditional Antidepressants Haven't Worked

Delivered by certified psychiatrists and therapists in Marlton, New Jersey.

Transcranial Magnetic Stimulation (TMS)

TMS is an FDA-approved, non-invasive treatment that uses magnetic pulses to stimulate specific areas of the brain involved in mood regulation. Unlike medications, TMS has minimal side effects and works directly on brain circuits affected by depression.

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Spravato (Esketamine)

Spravato is an FDA-approved nasal spray for treatment-resistant depression. It works differently from traditional antidepressants, targeting the glutamate system in the brain rather than serotonin. Many people see improvement within hours to days  rather than weeks.

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Challenges with Traditional Antidepressants

One of the largest studies on depression, the Sequenced Treatment Alternatives to Relieve Depression (STAR*D), found that the likelihood of experiencing significant symptom relief tends to decrease after failing multiple antidepressants.

While antidepressants help many people, some individuals stop treatment because they don’t feel enough improvement or experience unwanted side effects.

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Hope for Treatment-resistant Depression  in Marlton, New Jersey

Having treatment-resistant depression doesn't mean you're out of options. Our South Jersey team has extensive experience treating complex cases of depression. We stay current with the latest research and treatment innovations to offer you the best possible care.

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